Ibutamoren Mesylate is a substance that is associated with more discussions on online forums than actual clinical research. However, the…
Ibutamoren Mesylate is a substance that is associated with more discussions on online forums than actual clinical research. However, the research so far does support several benefits of ibutamoren, associated with its ability to increase growth hormone and IGF-1 levels. Read on to find out what these benefits are, whether ibutamoren can help you, and how to deal with potential side effects.Ibutamoren is frequently discussed on online forums for its muscle-building properties. It is available over the counter and used by those wishing to increase their growth hormone levels.
However, clinical studies of this compound are relatively few. In the text below, we will highlight what is known about ibutamoren so far.
Ibutamoren (also known as ibutamoren mesylate or MK-677), promotes the secretion of the growth hormone (GH) and increases insulin-like growth factor 1 (IGF-1) [R, R].
Ibutamoren increases growth hormone levels by mimicking the action of the hormone ghrelin and binding to one of the ghrelin receptors (GHSR) in the brain. Activated GHSR stimulates growth hormone release from the brainGHSR is found in brain regions that control appetite, pleasure, mood, biological rhythms, memory, and cognition [R]. Therefore, we can expect that ibutamoren may also affect these functions. However, so far, clinical studies describe only the effects ibutamoren has on appetite – and as expected, like ghrelin, ibutamoren increases it.
A great thing about ibutamoren is that it increases growth hormone levels with little or no increase in other hormones, such as cortisol [R, R]. Cortisol suppresses the immune system, reduces wound healing, and impairs learning and memory, and it’s usually not good to have this hormone elevated.Ibutamoren is frequently used as an anabolic substance, to increase lean body mass i.e. create bigger muscles. It is orally active and can be taken once a day. These are all benefits compared to other growth hormone stimulators.
As previously mentioned, ibutamoren increases growth hormone levels and IGF-1 [R, R]. Both growth hormone and IGF-1, in turn, increase muscle mass, muscle strength, and reduce body fat [R, R, R].
In 24 obese men, a two-month treatment (DB-RCT) with ibutamoren increased lean mass, and transiently increased basal metabolic rate (BMR)